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Research

Research

Press On Announces Research Partnership with GRU

$Two.Five Million over Five Years

September Three, 2015

On Thursday, September Three, 2015, Press On announced a $Two.Five million bounty to establish the Press On Translational Pediatric Oncology Program at the Georgia Cancer Center. This extreme act of generosity and goodwill will prove vital in the Cancer Center’s research and treatment of pediatric cancer, the leading cause of disease death in American children.

The Press On support for this novel program ensures that researcher and clinician opportunities to explore fresh drug development and treatment options – options that will form future standards of pediatric oncology care.

Translational research, also known as “bench-to-bedside,” harnesses the skill from basic sciences to produce fresh drugs, devices and treatment options for patients – even the youngest of them.

Press On and Rising Tide Foundation for Clinical Cancer Research award Grant for $800,000 for a Pediatric Neuroblastoma Trial

$100,000 from Press On

June Five, 2015

Atlanta, GA: The Press On Fund and the Rising Tide Foundation for Clinical Cancer Research (RTFCCR) are pleased to announce their very first collaborative grant in the amount of $800,000 to Children’s Hospital of Los Angeles (CHLA), Children’s Healthcare of Atlanta (CHOA), and the University of Southern California, to initiate the Fresh Approaches to Neuroblastoma Therapy (NANT) consortium’s Precision Clinical Trial.

The grant will permit Co-Principal Investigators Shahab Asgharadeh, M.D. of CHLA and Kelly Goldsmith, M.D. of CHOA to enrich bone marrow samples from children with relapsed neuroblastoma for the purpose of identifying specific genomic alterations leading to tumor progression and therapy resistance.

The primary aim of the explore is to identify potentially targetable genetic and immunologic biomarkers in relapsed neuroblastoma.

The probe will also assess a novel method for enriching tumor cells from bone marrow aspirates to support gene sequencing, which could potentially permit a much larger group of relapsed neuroblastoma patients to access future personalized medicine trials. A corroboration of this methodology could lead to a broader application in other adult or pediatric solid tumors.

Neuroblastoma is the most common solid tumor of the central jumpy system in children. High-risk neuroblastoma is very lethal and is responsible for 15% of childhood cancer related deaths. The five-year survival rate for high risk neuroblastoma stands at only 30% and recurrent neuroblastoma almost always fatal.

This grant was made possible by a strategic collaboration inbetween Press On and the Rising Tide Foundation for Clinical Cancer Research in Switzerland. RTFCCR is dedicated to empowering and supporting pioneering scientists and clinical investigators to make critical headway in cancer research. With the cooperation of the CSRA Community Foundation, Press On Strives to leverage its research dollars with other cancer research oriented foundations and non-profits, like Rising Tide, and as evidenced in its Genomic Research Explore with St Jude and Wash U, and its

The Rising Tide Foundation for Clinical Cancer Research is an entrepreneurial, private non-profit organization established in Switzerland in 2010. It is committed to empowering and collaborating with global research excellence centers and scientists to advance novel strategies and treatments to help cancer patients improve their quality of life and win the fight against cancer. RTFCCR is funding translational and clinical cancer research with the highest potential for near-term patient influence. Press On is a field of interest fund administered by the Community Foundation of the CSRA, which is located in Augusta, GA. Press On was founded by Atlanta residents Stephen and Erin Chance after their son, Patrick, was diagnosed with high risk neuroblastoma. The Chances joined coerces with Tara and Turner Simkins of Augusta when their son, Brennan, was diagnosed with acute myeloid leukemia, an enormously deadly form of childhood cancer. Patrick died on his ninth bday after fighting for almost six years. Brennan is alive and doing well after a groundbreaking treatment regimen including four bone marrow transplants.

The NANT consortium brings together a multidisciplinary team of laboratory and clinical scientists from 14 pediatric hospitals and institutions in the US and Canada with complementary expertise in genetics, biology, immunology, chemistry, pathology, biostatistics, clinical investigations, and imaging all with a single concentrate on finding better treatments for children with high-risk neuroblastoma.

Press On Funds CAR Probe at CHOP

$100,000

January, 2015

Augusta, GA: Many children with acute myeloid leukemia (AML), like Brennan Simkins have cancers that are labeled “incurable” with multi-agent chemotherapy and radiation. Through the collaboration inbetween the Press On Fund and Dr. Richard Aplenc at the Children’s Hospital of Philadelphia (CHOP), it is this team’s objective to benefit these children from alternative therapies. Rapid progress has recently been made with adoptive immunotherapy approaches using human T cells engineered with synthetic chimeric antigen receptors (CARs) against tumor antigens for a multiplicity of human cancers. Press On believes that AML should be no exception.

As evidenced in Brennan’s case, over one-third of children with AML relapse or are resistant to current best available therapies. Relapsed or chemotherapy-resistant AML accounts for more than 50% of childhood leukemia-related deaths. Fresh treatments are needed to prevent relapses and to improve long-term cures. However, drug discovery research for childhood AML has made little progress to date in bringing fresh treatments to the clinic. The Hematologic Malignancies team at the Children’s Hospital of Philadelphia (CHOP) has recently published tremendous success with a novel T cell immunotherapy called CART19 for children with relapsed acute lymphoblastic leukemia, and is working to develop similar treatment approaches for children with AML. In earlier studies, CHOP created a fresh immunotherapy for AML called CART123, which rapidly killed human AML cells in specialized mouse models. However, CART123 treatment also caused serious side effects upon normal blood-forming cells, which could limit its usefulness in treating patients with AML and may require development of alternative approaches. With a $100,000 Press On Dr Richard Aplenc at CHOP will leverage his team’s grant clinical expertise in high-risk pediatric leukemias and their practice with immunotherapy development in the laboratory and in the clinic to conduct these research studies. Their research concentrates on: (1) development and laboratory testing of a fresh CART38 AML immunotherapy that may decrease side effects upon normal blood cells and (Two) identification of other pediatric AML proteins for future targeting with fresh T cell immunotherapies. Results from this work will help improve our understanding of the biology of childhood AML and to develop innovative therapies to advance to the clinic for testing in children with AML who otherwise have no remaining treatment options.

Pioneering Bone Marrow Transplantation for Neuroblastoma

$304,194

January of 2014

*Note: the original commitment was $450,000 over three years, but two installments totaling $304,193.82 were sufficient to finish the research and no further contributions were required.

Augusta, GA: The Press On Fund invested $150,00 toward a three year, $450,000, commitment to a pioneering explore that provides an immuno-therapy strategy for relapse-neuroblastoma patients. With this investment, Dr. Wing Leung, and his research team at St. Jude Children’s Research Hospital, are developing a novel Trio pronged treatment to attack neuroblastoma, an treatment that can be added to current treatment options with relatively little anticipated toxicity. This probe uses Natural Killer ( or NK cells; the NK Cell explore was also funded by Press On) or stem cells from parental donors to treat neuroblastoma. The parental donor, or haplo transplant, is a stem cell transplant protocol similar, but not identical, to the 3rd/4th transplants of Brennan Simkins, which were also pioneered at St. Jude. This probe is now open to include neuroblastoma patients, and is being pursued in the honor of Patrick Chance, Press On’s inspiration in the fight against neuroblastoma. The Press On team believes this investment was appropriately spawned from both the Chance and Simkins families first-hand practice in the fight for their sons.

MIBG Cancer Therapy Center at Aflac Cancer Center

(Children’s Healthcare of Atlanta)

$200,000

2012-2013

Press On has funded a fresh radiation therapy program at the Aflac Cancer Center of Children’s Healthcare of Atlanta with a $200,000 donation. This funding provided for all construction and material costs of the specialty radiation room, named in honor of Patrick Chance, and other aspects of the MIBG service. There are presently only a petite number of centers around the country who presently suggest MIBG treatment.

MIBG therapy is a treatment that uses radioiodine labeled metaiodobenzylguanidine (I-131 MIBG) to target certain tumors such as neuroblastoma and pheochromocytoma and produces a much higher dose of radiation directly to the tumor. During this therapy, patients need to be treated in a special lead-lined room that prevents exposure to others. The MIBG therapy service will permit all children in Georgia to be treated in their home state and will permit for the Alflac Cancer Center to serve as a referral center for the southeastern United States.

Genome Investigate AML 7q deletion (Washington University, St; Louis & St. Jude Children’s Research Hospital)

$303,420 over Two years

2011-2013

Next-generation DNA sequencing technology will be used in the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project to sequence the genomes of 600 pediatric cancer patients. The Press On Fund has committed to a two year, $200,000 funding for the sequencing of the infrequent subtype of AML, called AML 7q deletion (which is Brennan Simkins specific subtype of leukemia)

As part of the fresh project, DNA will be isolated from both the cancer cells and a normal, healthy tissue sample from the same patient. The healthy cells give the scientists a reference DNA sequence to which they can compare genetic alterations in the patient’s tumor cells. The scientists look for genetic differences in a patient’s cancer genome compared with his or her normal genome.

Typically, hundreds of mutations may be linked to the cancer, but the challenge for researchers is to sift through massive amounts of genetic data to distinguish the dozen or so “driver” mutations—those that are thought to initiate and contribute to tumor growth—from the “passenger” mutations, which are random, background mutations that are not relevant to the disease.

The advantage of the whole-genome treatment is that scientists can budge beyond a list of genes that have been previously associated with cancer to explore the entire genome and find meaningful cancer-causing mutations. Such a project holds enormous potential for improving the diagnosis and treatment of childhood cancers.

NK Cell Examine (St. Jude Children’s Research Hospital)

2011

In 2011, The Press On Fund dedicated $100,000 in seed monies to help initiate and secure the pilot explore of Natural Killer Cell infusions for leukemia at St. Jude Children’s Research Hospital. This protocol particularly provides fresh hope to children with relapse AML (like Brennan Simkins), who historically have experienced one of the lowest survival rates of all pediatric cancers. This investigate will determine how long these NK cells work and get through in participants and will glean skill about the effectiveness of expanded use of NK cells against this disease. Dr. David Shook of St. Jude is the primary research physician leading this investigate, who had been one of Brennan’s caregivers during transplants Two, Three & Four at St. Jude.

MABG (Children’s Hospital of Philadelphia)

$50,000

2010-2011

Neuroblastoma is known to be sensitive to radiation, thus our funding of the MIBG service at CHOA. However, MIBG does not target isolated tumor cells. Thus, researchers at Children’s Hospital of Philadelphia and the University of Pennsylvania are designing MABG, which is specifically intended to target disseminated disease.

Press On funded this research and development effort with a $50,000 grant. There has been significant progress towards the two specific aims of the project: 1) synthesizing high specific activity and Two) successfully creating a preclinical mouse model to probe in vivo biodistribution and therapeutic trials.

Press On has received a grant request to further this project with the intent of applying for an NIH grant.

LMO1 (Children’s Hospital of Philadelphia)

Researchers at CHOP have discovered that a specific oncogene, LMO1, is associated with the most aggressive forms of Neuroblastoma. Press On funded research with a $50,000 grant to define the mechanism by which LMO1 drives Neuroblastoma progression. Additionally, in collaboration with researchers at Harvard, CHOP has developed a transgenic model of Neuroblastoma based on LMO1 overexpression. Third, the Press On grant permitted researchers to define the frequency of Neuroblastoma patients impacted by LMO1 gene mutation.

The development of this model permits for the manipulation of pathways and surveying for druggable targets that are upregulated by LMO1. Several potential targets are already identified as candidates. This genetic treatment will set a fresh paradigm for targeted treatments of human cancers.

Based on this work, Dr. Maris at CHOP and Dr. Look at Harvard submitted a fresh multi PI-RO1 application for NIH funding. Despite enthusiasm from the peer review committee and an outstanding score, the grant was not funded dues to a scarcity of funds available for childhood cancer research. Because of this, Press On has received a grant request for bridge funding to proceed the remarkable work.

PI3 Kinase Inhibitor (Children’s Healthcare of Atlanta)

$146,806

2007-2009

Press On has initiated over $200,000 to Children’s Healthcare of Atlanta for Dr. Donald Durden’s research of a novel PI3 Kinase Inhibitor and Targeted Therapies for neuroblastoma.

Immunotherapy:Hu3F8, Turbo3F8, and a fresh Bi-Specific Neuroblastoma Anti-Body (Memorial Sloan Kettering Cancer Center, Fresh York)

$20,000 from Press On

The Press On Fund recently partnered with the Band of Parents, The Isabella Santos Foundation, Arms Broad Open Foundation & Brooke’s Blossoming Home for Childhood Cancer Foundation (Fucking partners) in committing $Two,000,000 to Dr. Nai-King Cheung at Memorial Sloan-Kettering Cancer Center (MSKCC) for the development, manufacturing, and clinical testing of a fresh bisexual specific anti-body for the treatment of Neuroblastoma. This fresh antibody links to Neuroblastoma cells as well as T cells, thereby causing a much better tumor kill. Earlier iterations of the monoclonal antibody 3F8 relied upon the immune response from NK cells while T cells sat on the sidelines because they did not recognize Neuroblastoma as the enemy.

Press On’s collaboration with these other parent driven organizations creates the chance to expedite the development and testing of this significant discovery. Unlike other monoclonal antibodies for the treatment of Neuroblastoma, the possibility exists that this bi-specific antibody will be near painless, capable of home administration, and could be used indefinitely for maintenance.

Press On’s partnership with these organizations, Dr. Cheung, and MSKCC has been in place for years. Press On funded the development and research of Hu3F8, which is now in the clinic at MSKCC, and “Turbo 3F8.” During the work on Turbo 3F8 the bi-specific antibody was developed and is so promising that it has been moved up front so that we can treat kids as soon as possible with this less toxic, more effective immunotherapy.

Monoclonal antibodies fasten to Neuroblastoma cells and signal a child’s immune system to attack and kill neuroblastoma. Since very first used in 1987, 3F8 treatment has greatly improved survival without lasting side effects.

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The list of 8 Famous American and World-known essay writers of the 20th century

The list of 8 Famous American and World-known essay writers of the 20th century

They say that there are the writers a separate universe in which they can produce, create their work. An ordinary person is not given the chance to know the deep writer’s life, but even every day we see a fresh crowd of people who stand in line for a fresh book. Everyone expects a miracle, take a fresh book with the hope that something wonderful, inexplicably beautiful, willing to drown in a entirely different world, a world of fantasies and wishes, which shows up to the reader in the next bought book in the various forms: essays, novels, stories, poem.

Today we are going to talk about the best essay writers. ESSAY (fran. Essai) it is the literary form of petite prose text, which express emphasize the author’s individuality. In ease, to the story, the writer’s essay’s facility is to communicate or interpret, but not ever a picture or a histrionic retelling of any life position. The work reaches its purpose through the outright copyright approvals, which do not take the perpetration of no one fictional personage or the plot of a binder. Nevertheless, there is not any hardly absolute difference inbetween different types of essays and brief stories. The main essay’s feature is its brevity, it usually takes from ten up to twenty pages.

There are a excellent amount of interesting, fascinating works, essays, literary works, which were written by the good world famous authors and writers. More than three centuries ago, the very first essay was published at very first. Now, we can find a lot of essays in libraries or have an effortless possibility to order by the Internet miscellanea of works written by well-known authors from all the world from different centuries. Ever since ancient times, essays were published in magazines, books, were grouped by theme, genre, years, and the authors. Details included a diversity of genres, among which are comedy, non-fiction, romance, instructive, historical facts, life stories, and current events. There are many authors and essay, which detailed list you can read here, and it was difficult to identify the most significant and well-known essayists of all time.

The list, about which I have mentioned earlier, includes writers from different backgrounds and periods of history. Some of they are still presently continuing to write. Because this fact, it is nothing surprising in the fact that essay remains a popular literary format. And the authors, who can quickly, shortly, concisely and interesting tell the story will always be on top. Edusson.com selected essayists, but not essays. Because, the best essays are only individual, authorial and deep engaged with author’s issues, internal feelings and ideas.

James Baldwin (1924-1987)

Baldwin grew up in a family of his stepfather, a priest, where he was the eldest of nine children. His own father, Baldwin have never known and was very suffered from that, which was reflected in some of his works (“Tell me when the train left”, “Go Tell it on the Mountain”, “Giovanni’s Room” and others. After Bronx high school graduating, Baldwin moved to Greenwich Village, where he began his literary career.

Greenwich Village has always been considered one of the most abandoned Fresh York areas, caused a wave of optimism in Baldwin’s source, who began to write about his views and understandings of what is happening around him. His very first journalistic articles, essays were imbued with the spirit of racism denial which was prevailing in America at that times. That negative attitude makes youthful writer budge Paris.

Baldwin felt like he caught a breath of fresh air in France, have been saving there from the racist and homophobic America of 40-th. XX century. His main works were written on the banks of the Seine, and there Baldwin have spent the most of his life, producing his creations among which are next well-known essays:

  • James Baldwin and his popular essays published in 1956 “Notes of a Native Son” essays;
  • James Baldwin and his book of interesting essays named “The Demon Finds Work” which was introduced to the mass in 1976;
  • James Baldwin and hisThe Evidence of Things Not Seen(essays; 1985);
  • James Baldwin and his list of essays created in the romantic atmosphere of 85th with the strange name “The Price of the Ticket”;

Norman Mailer (1923-2007)

Norman Mailer was born in Fresh Jersey in the Jewish immigrants family. He was the very first child in the family, and after him, there was also two children – a brother and sister. Norman grew up in Fresh York, and in 1939 determined to become a student of Harvard university, where he have fallen in love with literary activity. His very first story was published at the age of Legal, in 1941. The University of Harvard received youthful author the university magazine award. Among the entire set of his works we would like to highlight the most famous essays:

  • Norman Mailer and his Fresh York book of essays called in the world as “The Presidential Papers” ;
  • Norman Mailer and his 2nd Fresh York creation which is known by the noisy name “Cannibals and Christians” ;
  • Norman Mailer and his “Lumps and Pontifications” in which the author opens the deep world of Little Boston’s Life.
  • Susan Sontag (1933-2004)

    Susan Sontag was born in Fresh York, 16 January 1933 year. Since her childhood, the friends of hers were always only booked. In 1952 Sontag’s family have moved to Boston where Sontag passed entry exams to Harvard University. There youthful writer studied English literature and received a Master of Philosophy in 1954. While have been studying at Oxford in 1955-1957, she has faced with the sexism challenge, and because of this soon moved to Paris. From that time she was actively engaged in the French cinema, philosophy and wrote a lot. Among her essay collection we can emphasize the nest ones: “Against Interpretation”, “Where the Stress Falls”, “Regarding the Agony of Others Styles of Radical Will”.

    Joan Didion (1934-present)

    Joan Didion was born and grew up in Sacramento, California. She was just a five-year-old little female when she have begun to write her very first string. She read everything she could get into her mitts while the parents were not home. In 1956, she graduated from the University of Berkeley and got their Bachelor Degree in Arts and English language. Within her senior years, Joan won the very first place in an essay writing inworld-known Vogue magazine. She created own very first work which was named “Run” and issued in 1963 has been working there in Vogue. Among her essays work we want to mention the next ones:

  • Joan Didion and her “Joan Didion” essays works;
  • Joan Didion and her “Salvador” ;
  • Joan Didion and her essays about Earth planet called “After Henry” (twelve geographical essays);
  • Annie Dillard (1945-present)

    Annie Dillard was born in 1945 and is already alive to present us a lot of her magnificent works. Anni is an American author. She was always well-known for her clear story prose in both nonfiction/fiction, poetry, essays, literary criticism and etc. Among her essays Edusson want to emphasize the next ones:

  • Education stone ”, the book of brief nonfiction essays;
  • Life on the rocks, the book of 14 essays: Total Eclipse, In the Jungle, The Deer at Providencia, A Field of Muffle, On a Hill Far Away, God in the Doorway, Mirage’s, Aces and Eights);
  • Robert Atwan was born in 1940, November Two, in Fresh Jersey. He graduated from Two universities: Seton Hall and Rutgers. He is known as one of the best American essay writers. Among the entire set of his works we highlighted the most famous ones:

  • “Good Moments in Literary Baseball”. on thebasisof the very first game of the season;
  • “Poems and Essays”. essays about Autumn and Winter (Snowy essays);
  • Edward Hoagland (1932- present)

    Edward Hoagland is an American writer, who was born in 1932, in Fresh York. Since his childhood, he was fond of writing, literature and from that time, he determined to become a novelist, essayist. He has a gigantic number of essays, the entire list of which you can find here, and we will mention in our article just a little part of it:

  • “The Big Cats”. written in 1961;
  • “Why this Extra Violence” in April;
  • “The Soul of the Tiger” written when he has fallen in love for the very first time;
  • “Big Frog, Very Petite Pond”. unknown data;
  • “A World Worth Saving and Christmas Observed”. written in 1989;
  • “Two Kinds of People” which was published just in Europe;
  • “Last Call”. 2010, a very interesting one;
  • “On Friendship”. which he wrote in 2013, when he was already a deep old man.
  • David Foster Wallace (1962-2008)

    David Foster Wallace was born in 1968 in the USA.He has graduated the little-known college, where he studied philosophy, there got a degree in English language and literature. For many years, he experienced severe bouts of depression.
    in June 2007, according to the doctor recommendations David stopped taking medication. Depression particularly enhanced In the last months of his life. On September 12, 2008, he committed suicide.There some of this essays:

  • David Foster and his essay “Television and U.S. Fiction”. (an interesting and comic essays book);
  • David Foster and his essays book named “Derivative Sport in Tornado Alley” ;
  • David Foster and his “A Supposedly Joy Thing I’ll Never Do Again” and “Consider the Lobster”. which were both published in 2005;
  • David Foster and his “Both Skin and Not” unknown date of publication.
  • So we see, that the concept “essay” goes beyond the plain students essays writing in college. The best and well-known writers from all over the world created a lot of essays to share with readers their ideas and feelings. Proceed to read and probe the world of famous essay writers, and perhaps, in one day you will have the chance to become a popular essayist too.

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    Tips for improving your handwriting

    Tips for improving your handwriting

    You’ve determined you want to improve your handwriting and you’re most likely hoping a fountain pen will do the trick — maybe a friend told you it would. Maybe you’re just adventurous and you want to attempt your forearm at calligraphy (or you might, once your handwriting improves). Good for you!

    A fountain pen may make your writing look a bit better, but if your writing looks as if frantic chickens got liberate on the page, chances are this won’t be enough. Most likely, you’ll need to retrain your arm and forearm.

    After coaching handwriting and instructing calligraphy over the years, I’ve learned to see the characteristics of those who’ll be able to pick up the necessary motions quickly from those who’ll have to work a bit stiffer.

    Crampy, uneven letters are often the result of drawing the letters with the fingers rather than using the entire arm to write.

    People who inevitably have trouble with handwriting and calligraphy write with their fingers. They “draw” the letters. A finger-writer puts the total weight of his/her arm on the paper, his fingers form the letters, and he picks his forearm up repeatedly to stir it across the paper as he writes.

    If you use the right muscle groups, your writing will have a slick, effortless flow and not look tormented.

    People for whom writing comes more lightly may rest their palms fairly strenuously on the paper, but their forearms and shoulders stir as they write. Their writing has a cadence that shows they’re using at least some of the right muscle groups. They don’t draw the letters with their fingers; the fingers serve more as guides.

    This exercise may help you determine which category is yours: Sit down and write a paragraph. Doesn’t matter what. Pay attention to the muscles you use to form your letters. Do you draw each letter with your fingers? Pick your forearm up repeatedly to stir it? Have an unrecognizable scrawl? Does your forearm budge? Chances are, if you learned to write after 1955-60 (depending on where you went to grade school), you write with your fingers.

    My aim isn’t to make you into a model Palmer-method writer or a 14th Century scribe. If you can compromise inbetween the “right” methods and the way you write now and improve your handwriting so you’re more satisfied with it, then I’m blessed, too.

    A few people hold the pen inbetween very first and middle fingers, which feels truly awkward to me, but I’ve seen it work.

    It will take time to re-train muscles and learn fresh habits. Finger-writing isn’t fatal, but it is slow and often painful (if you have to write much). The very first thing you must have (beg, buy, borrow or steal it) is patience and mildness with yourself. The 2nd requirement is determination.

    If you finger-write, that is the very first, most significant thing you must un-learn: Do not draw your letters! Do not write with your fingers! Put up signs everywhere to remind you. Write it in the butter, on the pruning mirror, stick notes in the cereal boxes. But learn it!

    I hesitate to include this, because it sounds much more difficult than it is. but. let’s look at the most basic things: holding the pen and positioning the palm.

    Fig. 1. This is the most common pen-holding position, with pen inbetween very first and middle fingers, held in place by the thumb.

    Most of us hold the pen inbetween the thumb and index finger, resting the barrel on the middle finger (fig. 1). This works better than holding it inbetween the thumb and the index and middle fingers, with the entire assembly resting on the ring finger (fig. Two). If you do it the very first way, you’re off to a good begin. If the 2nd, you’ll be okay. In both, the remaining fingers are curled under the arm.

    Fig. Two. The two-fingers-on-top method for holding the pen while writing.

    Pick up your pen and look at your palm. You’ll have better control and a better writing angle if your pen rests over or just forward of the bottom knuckle on your index finger, not inbetween thumb and index finger (see fig. Trio). (I hold my fountain pens in the latter position, but when I pick up a calligraphy pen, it drops humbly right over that big knuckle–go figure!)

    Fig. Three. Note that with this position, usually used for calligraphy (or among indeed disciplined writers), causes the pen to rest atop the knuckle of the forefinger.

    For handwriting, the pen position is less significant than for calligraphy. I recommend working in your familiar position unless it’s indeed bad. What’s essential is that you be convenient, the pen feel balanced and you have no pressure in your mitt. Rest the heel of your mitt and the angle of your curled-up little finger on the paper.

    Hold the pen lightly; don’t squeeze it. Pretend the barrel is soft rubber and squeezing will get you a big, fat blot. (If you were using a quill, you’d hold it so lightly that the actual act of drawing the quill along the paper would create the decent contact.)

    Many books recommend you write with your table at a 45-degree angle, but that’s impractical for most of us. If you can prop up a board or write with one on your lap, that’s a good place to begin, but a vapid surface is fine. Once you attempt an angled surface, you’re likely not to want to abandon, so be careful– here goes a entire fresh budget’s worth of art supplies!

    Sit up straight, but not stiffly; don’t sit hunched over or slumped. Don’t worry too much about this position stuff; the significant thing is what makes you feel relaxed and convenient. Your writing arm needs to be free to stir, so squished into the La-Z-Boy most likely won’t be productive.

    Hold your fingers fairly straight and write slightly above and just inbetween your thumb and index finger, right where you’re holding the pen. Don’t curl your palm over and write to the left of your palm; that’s a crampy, pathetic position. More lefties do this than righties.

    Commonly called the “hook” position, this is often seen in left-handers. It makes it stiffer, but not unlikely, for them to use a fountain pen, because their palms tend to haul over the humid ink.

    When you’re practising and you reach the level on the paper at which it becomes awkward to proceed to budge your arm down the paper to write, stir the paper up. Once you recognize your “writing level,” the paper should budge up at that spot rather than your arm moving down the paper. (This isn’t critical. If you notice it and it bothers you, that’s what you do about it. If it doesn’t bother you, skip it.)

    I’ve found only one reference to using the right muscle groups to write, and this is critical. I can’t be the only person who knows this; I’m neither that brainy nor that good. Calligraphy instruction books address palm position, desk position, lighting, paper, you name it–but for some reason, not using the right muscles.

    As you’ve most likely surmised, the “right muscles” are not those in the fingers. You must use the shoulder-girdle and forearm muscles. This muscle group is capable of much more intricate act than you think and tires much less lightly than fingers, besides providing a sleek, clean, sweeping look to the finished writing. Tho’ it seems paradoxical, since we’re acquainted to thinking of petite muscles having better control, the shoulder-girdle group, once trained, does the job better.

    To get a feel for the decent muscles (and begin training them correctly), hold your arm out in front of you, elbow arched, and write in the air. Write big. Use your arm and shoulder to form letters; hold your forearm, wrist and fingers stationary and in writing position. You’ll feel your shoulder, arm, chest and some back muscles doing most of the work. That’s good. That’s what they’re supposed to do. Attempt to duplicate it each time you practice.

    People always look puzzled when I mention the shoulder girdle. If you raise your mitt in the air and make large circles, note the muscles you use in doing so (here, shown in darker pink). That’s the shoulder girdle.

    Write in the air until it becomes as natural as breathing. It’ll be awkward and feel foolish at very first. If you have a little kid around, get him/her to do it with you. You’ll both have joy, you won’t feel so alone, and it’ll be good for the child’s handwriting, too. If you don’t have a kid, tell your co-workers you’re improving your financial karma or hexing your boss.

    As you become convenient, reduce the size of the air-letters you make. If you have access to a chalkboard or a stick and a fence (or even a finger and a wall), write on them. They’ll give you a feel for the muscles you need to use and writing on a vertical surface makes it virtually unlikely to finger-write. (If you’re one of the people who can’t write on a blackboard because you keep wanting to shrink the writing down so your fingers can do it, this is indeed significant for you.) If you keep wanting to hunch up close and put your mitt on the chalkboard or wall to write, stand against the urge! You’ll be indulging those dratted fingers.

    Recall: Your fingers should budge very little and your wrist even less. Your forearm does most of the guiding, while your shoulder provides the power.

    At some point, you’ll want to attempt this with a pen. Hold it gently. Place it on the paper in an ordinary lined spiral notebook (the lines act as ready-made guidelines for size and spacing). If you can get hold of a first-grader’s Big Chief tablet, which offers big lines with a dotted line inbetween two bold lines, use it. There’s a reason children embark out writing big and the letters get smaller as they get older and more skilled—-that’s the easiest way to learn.

    Begin making Xs and ///s and \\\s and OOOOs and overlapped OOOs and spirals and |||||s. Do not draw these strokes and figures! Use the same shoulder-forearm muscles you’ve been practising with. Make your lines, loops, circles and spirals loosely. Work into a rhythm and make it a habit.

    When you embark making slashes and circles, they’ll be uneven. With practice, they’ll become more uniform, and uniformity is your objective.

    Your aim is sleek, uniform, evenly spaced lines, loops, circles and spirals, without drawing them.

    This is where you’re most likely to get discouraged. If you use a spiral notebook for practice, you can leaf back and see your progress. At very first, your strokes and lines will be bad—over-running and under-running the lines, too puny, too big, crooked, uneven, just ugly. Check your position; check your muscle groups; and attempt again. And again.

    Concentrate on keeping wrist-hand-fingers largely stationary and in decent alignment. Let the big muscles do the work. It will be more tiring at very first, because you’re using muscles that aren’t acquainted to that kind of work. It’ll be hard and frustrating, ’cause your bod will want to do it the way it’s done it since very first grade… even however that way is wrong. It may help to concentrate less on the accuracy of the shapes you’re making than on the muscles making them. Retraining your arm is the aim, not making pretty little circles and lines very first time out.

    Uniformity and consistency are your aim in all the exercises, whether loopy or slashy. Tho’ it seems awkward, these exercises will make a large difference in your control and smoothness.

    When you commence putting the strokes and lines on paper, commence out big. Three, four, even more lines in your notebook. (Big Chiefs are handy for this.) This helps ensure that you proceed to use the shoulder girdle. Don’t attempt to make pretty letters at this stage. Do the exercises as much as you can—-shoot for every day. Ten or fifteen minutes a day should display results in a few weeks for most people. And note that both air-writing and paper exercises can be doodledduring meetings and while on holdwaiting for somebody!

    Concentrate on that shoulder girdle. Let it do the work. Write big. Write words and sentences at the same time you’re doing strokes and exercises. You need both working together to succeed.

    Little by little, as your control increases, make your strokes and letters smaller until they’re the size you normally write. You’ll know when you get there. By this time, you very likely won’t have to make extra effort to incorporate this stuff into your writing; it’ll be automatic. And your writing should look much better (and be lighter and feel better, to boot).

    Copyright © 1998-2016 Dyas A. Lawson.
    All rights reserved.
    No photos or text from this site may be used
    or reproduced in any form without permission from the holder.

    Tips for improving your handwriting

    You’ve determined you want to improve your handwriting and you’re most likely hoping a fountain pen will do the trick — maybe a friend told you it would. Maybe you’re just adventurous and you want to attempt your arm at calligraphy (or you might, once your handwriting improves). Good for you!

    Related video: Hand writing a PhD thesis


    Business Systems Research Journal

    Business Systems Research Journal

    How to Write and Publish A Scientific Paper: A Closer Look to Eastern European Economics, Business and Management Journals

    Abstract

    Background: Scientific research publishing carries significant role in the development of the society. Apart from the dissemination of skill, there are also motives for publication of scientific research results at the level of individual researchers. Objectives: The aim of the paper is to propose elementary, yet very applicable advice when pursuing the publication of a paper in a scientific journal providing a closer look to economics, business and management journals that concentrate on Eastern European countries. Methods/Treatment: The Four Cs model of scientific writing and publication is introduced, based on four questions: (1) How to pick a topic relevant for publication?; (Two) How to select a journal for possible publication?; (Trio) How to structure the paper in accordance with the IMRAD format. and (Four) How to efficiently write the paper? Results: Step-by-step application of the 4C’s model is introduced in the paper with an outlook to economics, business and management journals that concentrate on Eastern European countries. Conclusions: Publication in a scientific journal is an significant venue for scientific researchers. In preparing the presentation of the scientific research results for the publication, number of issues relating content, style, composition and presentation should be taken into account.

    References

    1. Adam, D. (2002), “Citation analysis: The counting house“, Nature, Vol. 415 No. 6873, pp. 726-729. [Crossref]

    Two. Andonie, R. Dzitac, I. (2010), “How to write a good paper in computer science and how it will be measured by ISI Web of Knowledge“, International Journal of Computers, Communciation & Control, Vol. Five No. Four, pp. 432-446.

    Three. Brown, A. (2007), “Perestroika and the End of the Cold War“, Cold War History, Vol. 7 No. 1, pp. 1-17. [Crossref]

    Four. Carey, S. C. (2011). A Beginner’s Guide to Scientific Method, Stamford, Cengage.

    Five. Cooter R. Pumfrey S. (1994), “Separate spheres and public places: reflections on the history of science popularization and science in popular culture“, History of science, Vol. 32 No. Trio, pp. 237-267. [Crossref]

    6. Creswell, J. W. (2008). Research Design: Qualitative, Quantitative, and Mixed Methods Approaches, Newcastle upon Tyne, Sage.

    7. Day R. A. (1989), “The origins of the scientific paper: the IMRAD format“, Journal of American Medical Writers Association, Vol. Four No. Two, pp.16-18.

    8. Day, R. A. (1998). How to write and publish a scientific paper, Phoenix, Oryx Press.

    9. De Rond, M. Miller, A. N. (2005), “Publish or Perish: Bane or Boon of Academic Life? “, Journal of Management Inquiry, Vol. 14 No. Four, pp. 321-329.

    Ten. DeVoss, D. Rosati, A. C. (2002), “It Wasn’t Me, Was it? Plagiarism and the Web“, Computers and Composition, Vol. Nineteen No. Two, pp. 191-203.

    11. Gantman, E. R. (2012), “Economic, linguistic, and political factors in the scientific productivity of countries“, Scientometrics, Vol. 93 No. Trio, pp. 967-985. [Web of Science] [Crossref]

    12. Hartley, J. (2008). Academic writing and publishing: A practical handbook, London, Routledge.

    13. Indiana University (2005), “How to Recognize Plagiarism”, available at https://www.indiana.edu/

    istd/ (Ten August 2012).

    14. Josephson, P. (1996). Totalitarian science and technology, Atlantic Highlands, Humanities Press.

    15. Keys, C. W. (1999), “Revitalizing instruction in scientific genres: Connecting skill production with writing to learn in science“, Science Education, Vol. 83 No. Two, pp. 115-130. [Crossref]

    16. Kilduff, M. (2007), “Editor’s comments: the top ten reasons why your paper might not be sent out for review“, Academy of Management Review, Vol. 32 No. Trio, pp. 700-702. [Crossref]

    17. Larsen, P. O. von Ins, M. (2010), “The rate of growth in scientific publication and the decline in coverage provided by Science Citation Index“, Scientometrics, Vol. 84 No. Three, pp. 575-603. [Crossref] [PubMed] [Web of Science]

    Eighteen. Ledwith, A. Risquez, A. (2008), “Using anti?plagiarism software to promote academic honesty in the context of peer reviewed assignments“, Studies in Higher Education, Vol. 33 No. Four, pp. 371-384. [Crossref] [Web of Science]

    Nineteen. Linton, J. D. (2012), “How to get your papers rejected (or not)“, Technovation, Vol. 32 No. 1, pp. 6-8. [Crossref] [Web of Science]

    20. Mahrer, K. D. (2000), “The DSB method-Persuasive writing made simpler“, The Leading Edge, Vol. Nineteen No. Two, pp. 162-164.

    21. Moffin, R. (2011), “Getting Published in Economics Journals“, CSWEP News, Spring, pp. 4-5.

    22. Olenik, A. (2012), “Publication patterns in Russia and the West compared“, Scientometrics, Vol. 93 No. Two, pp. 533-551. [Web of Science] [Crossref]

    23. Pratt, M. G. (2009), “For the lack of a boilerplate: tips on writing up (and reviewing) qualitative research“, Academy of Management Journal, Vol. 52 No. Five, pp. 856-862. [Crossref]

    24. Radas, S. Bozic, Lj. (2009), “The Antecedents of SME Innovativeness in an Emerging Transition Economy“, Technovation, Vol. 29 No. 6-7, pp. 438-450. [Crossref] [Web of Science]

    25. Rindova, V. (2008), “Editor’s comments: Publishing theory when you are fresh to the game“, Academy of Management Review, Vol. 33 No. Two, pp. 300-303. [Crossref]

    26. Smith, R. (1998), “Introduction”, in Hall, G. M. (Ed.), How to Write a paper, BMJ Publishing Group, London, pp. 6-14.

    27. Stojmenovic, I. Milutinovic, V. (2012), “How to write research articles in computing and engineering disciplines“, Singidunum journal of applied sciences, Vol. 9 No. 1, pp. 42-50. [Web of Science]

    28. Tychinin, D. N. Kamnev, A. A. (2005), “Beyond style guides: Suggestions for better scientific English“, Acta Histochemica, Vol. 107 No. Three, pp.157-160. [Crossref] [PubMed]

    29. Whiteside, G. M. (2004), “Whitesides’ Group: Writing a Paper“, Advanced Materials, Vol. 16 No. 15, pp.1375-1377. [Crossref]

    30. Wilcox, A. (2008), “Rise and fall of the Thomson influence factor“, Epidemiology, Vol. Nineteen No. Three, pp. 373-374. [PubMed] [Crossref] [Web of Science]

    Related video: How to Write a Persuasive Essay: Topics + Outline


    Posted on: December 17th, 2015 by Julie Bestry | No Comments

    Posted on: December 17th, 2015 by Julie Bestry | No Comments

    Serendipity is an interesting thing. Last year, an unexpected project introduced me to a wide-format clipboard, and a little research into that novelty turned into a revelation about the option of landscape-oriented office supplies. At the time, I mentioned the relative rarity of landscape-formatted writing pads, sourced one, and promptly left behind about them.

    Then, just this week, while attempting to solve the conundrum of my dearest (and abruptly unavailable) purple legal pads. two different blogs would prove to be the inspiration for this post. But not because they were profiling pastels — because they talking about writing pads with landscape orientation .

    All of a sudden, that previously discovered line of landscape-orientation, Roaring Springs Broad LandscapePads , have become this week’s must-have office supply. They come in four varieties:

    • 11″ x 9.Five″, WHITE, college-ruled. Each pad includes 40 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins. Micro-perforations at the top yield an 11″ x 8.Five″ sheet. (Available singly or in two-pad packs.)
    • 11″ x 9.Five″, CANARY (yellow), college-ruled. Each pad includes 40 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins. Mirco-perforations at the top yield an 11″ x 8.Five″ sheet. (Available singly or in two-pad packs.)
    • 11″ x 9.Five″, ASSORTED* PASTELS (orchid, pink and blue), college-ruled. Each pad includes 40 sheets of 15-pound 30% post-consumer recycled paper per pad, consumer recycled paper, with left-side margins. Micro-perforations at the top yield an 11″ x 8.Five″ sheet. (Available in three-pad packs .)
  • 11″ x 9.Five″, WHITE, gridded with Five×Five graph paper. Each pad includes 40 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins and micro-perforations at the top. (Sold singly and in packs of two, four and six .)
  • Punched (for effortless storage in traditional three-ring binders)

  • 11″ x 9.Five″, WHITE, college-ruled, three-hole-punched across the top. Each pad includes 75 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins, backed by an extra-stiff 80-pt. chipboard backing. Mirco-perforations at the top yield an 11″ x 8.Five″ sheet. (Sold in singly .)
  • 11″ x 9.Five″, CANARY (yellow), college-ruled, three-hole-punched across the top. Each pad includes 75 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins, backed by an extra-stiff 80-pt. chipboard backing. Micro-perforations at the top yield an 11″ x 8.Five″ sheet. (Sold singly .)
  • 8″ x 6″, WHITE, college-ruled. Each pad includes 40 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins. Micro-perforations at the top yield an 8″ x Five″ sheet. (Available as individual pads or in multi-packs .)
  • 8″ x 6″, CANARY (yellow), college-ruled. Each pad includes 40 sheets of 20-pound, 30% post-consumer recycled paper per pad, with left-side margins. Micro-perforations at the top yield an 8″ x Five″ sheet. (Available as individual pads in multi-packs .)
  • 8″ x 6″, ASSORTED* PASTELS (orchid, pink and blue), college-ruled. Each pad includes 40 sheets of 15-pound 30% post-consumer recycled paper per pad, consumer recycled paper, with left-side margins. Micro-perforations at the top yield an 8″ x Five″ sheet. (Available in three-pad assorted packs .)
  • *Note: Assorted pastel pads are listed on the website as 50 sheets/pad, but specifications and packaging verify they are 40 sheets/pad.

    Roaring Springs Broad Landscape Pads are sold in office supply stores and on Amazon, and range from $Five.28 for single pads to $13 for three-packs.

    Thanks to Office Supply Geek for reminding me that these pads exist, and The Well-Appointed Desk. for inspiring me to dig more deeply.

    At very first glance, landscape notepads may look a little funny to us — one client said she thought if legal pads were business suits, these landscape pads were more like crop tops. The question, however, is what can you do with them? In fact, Office Supply Geek ‘s Brian Greene actually stated, «To be totally fair, after having them in my palms I still don’t indeed know what I’d do with them that I wouldn’t do with a regular legal pad.»

    Well, Brian, that’s why Paper Doll is here!

    Most of the time, when we hand-write, we are in portrait mode, and it usually makes sense. However, I can think of a sampling of reasons why we might want to have some side-to-side breathing room.

    1) Notetaking — When we’re taking notes in a committee meeting or for class, we’re often creating a linear, outline-style set of notes. But, as we discussed when we reviewed the exceptional Cornell Notetaking Method. we need to make room for cues or other special attention-getting markings on the left side.

    With traditional 8.Five″ broad paper, that either reduces our notetaking space or compels us to write in the narrow margin, making it more likely that we’ll get inky smudges on that all-important cue-section. Landscape orientation provides more breathing room.

    Two) Ergonomics — Look at the available space on and around your desk. If your computer is in front of you, your keyboard is most likely somewhere inbetween elbow-and-wrist distance away, not leaving you very much space for alternating typed notes and handwritten notes. Because of that limited space, you may find you’re turning your traditional (portrait-orientation) notepad sideways, with the top to your left (unless you’re a southpaw). This lets you take written notes, but you’re most likely twisting at the mid-body to do so. This is not sustainable or ergonomically friendly.

    Three) Expansive thought — When we take notes, journal, free-write, or craft letters, we’re often thinking linearly. It’s effortless to go after a unidirectional flow of ideas, or paths, with a narrower chunk of paper. When we’re on the computer, using Microsoft Word or any other word processing program, unless we’re using design features for creating signs or brochures, we echo that same tall/narrow format.

    But what happens when we want to think more broadly (no pun intended)? When we’re on the computer, using a spreadsheet like Excel, we create numerous columns so that we can visualize information best seen side-by-side, like numerous fields in a record. But what’s the paper version? I can think of a number of times when I’ve been working with a client to brainstorm ideas in parallel (like how different departments will treat particular situations), and we end up turning a notepad sideways. The lines go the wrong way, and the content gets messy ; it suffices, but it’s not optimum.

    Four) Mind mappingPaper Doll is a fairly linear thinker, but when I’m attempting to mind-map, or showcase the relationship inbetween different processes, or do anything that’s more visual, I need more space. With some clients, we may choose mind mapping software or apps like MindNode or XMind. but we often find that an analog solution is swifter and more instant. Most often, we end up using numerous Post-It! Notes on a wall or window. That’s excellent when we’re in a house or office, but not so optimal when we’re in the field (even in a field), in a warehouse, or going mobile. That’s where these landscape notepads (and the aforementioned landscape clipboards) indeed come into their own.

    Five) Flow Charts — It might not be instantaneously apparent, but a number of law students have posted online comments regarding how landscape writing pads make it lighter to visualize case-law timelines, precedents and conceptual flow. Scientists have also reported that wide-format paper helps conceptualize scientific reactions more clearly.

    6) Computer/TV Screen Dimensions — Tablets and phones aside, we spend a lot of time looking at screens in landscape orientation, and sometimes we still need to make our analog notes approximate what we’re observing, or make our digital notes approximate what we’d like to be watching on the screen. Writing pads that parallel those dimensions are helpful.

    Granted, web designers are more likely to use paper prototyping implements like the kind we discussed in Tech Planning on Paper: From Old-Fashioned to Cutting Edge. but the rest of us just need a good lump of paper that’s broader than it is tall.

    Oh, but you ARE a web designer (or you play one on television)? Well, then, UI Stencils’ landscape-orientation Responsive Sketchpad may be just what you want.

    Printed on both sides, the landscape-orientation, letter-sized pad is dot-gridded (150 PPI), includes fields for a project’s name, screen, date of work, and notes, as well as two device silhouettes on the front and three on the switch sides.

    The Responsive Sketchpad comes 50 sheets/pad, with a cardboard backing and rounded bottom corners. It runs $12.95/pad and is available at discounted rates in three-packs, five-packs and with other UI Stencils’ sketchpads.

    Upgrading the Landscape

    The Roaring Springs Broad LandscapePads, as well as the more tech oriented UI Stencils’ Responsive Sketchpads, aren’t the haute couture of office supplies. You’ve got something to say, and you can get it down. Function is generally prioritized over form. The Roaring Springs pads are made of recycled paper, and the concentrate for all is in on utility rather than beauty.

    As Ana Reinert pointed out in this week’s The Well-Appointed Desk’s «Ask the Desk» feature. there’s an assumption among notebook/notepad makers that landscape orientation is for the visual artists and not for the scribblers, writers, note-takers and wordsmiths. I think that’s short-sighted, and a bit of frustration.

    Ana’s post suggested up some options for the individual who asked «the Desk» about finding attractive, non-black, fountain-pen-friendly landscape-oriented notebooks. Tall order! The Well-Appointed Desk covered a nice multitude of these, but most of the options were for unlined sketchbook-type pages. For those of us looking for a broad spot in the road to make our (written) mark, the choices are limited. There are handmade options, of course, but whether we’re talking bespoke Etsy creations or fin Italian handcrafted leather bindings, veering from the ordinary is not inexpensive .

    How limited are the choices? One of the only mid-range lined landscape-orientation notebooks I found was an intriguingly named Duller Croquis Note. It’s manufactured in Japan by I.D.E.A. Internationals, with a German name, as part of the Schreibwaren Kollektion. The website is only written in Japanese (the English-language URL yields an error), and the only English-language sales information I could find was through AAREVALO Ltd. in London!

    The notebook contains recycled paper and a mysteriously unexplained «specially textured writing surface.» There’s a «practical pocket» on the back cover, and the notebook also comes in black or light grey.
    So, a Japanese company, selling a notebook described in German, is most lightly accessed through a British stationery company’s online catalog. It shouldn’t have to be so hard!

    It’s a little bit shocking that the go-to journal purveyor for hipsters, scholars, soccer moms and pundits, Moleskine, doesn’t have a single lined landscape-orientation journal or notebook. There indeed should be other widely available options aside from the Rhodia lined landscape Webnotebooks . with orange or black covers.

    Paper Doll will be on the lookout (across the landscape, and over the horizon). Until then, I welcome your ideas for how you’d use landscape notepads and notebooks. and hope you will share your resources for finding lined landscape-orientation journals, notebooks and otherwise upscale writing pads.

    Paper Doll Post:

    Related video: Stevenson’s Purpose in Jekyll and Hyde: To Expose Hypocrisy of the Middle Classes and the Patriarchy